Keep mild-to-moderate depression, differing omega-3 formulations, major drug interactions and uncertain findings separate. This is not a general mood-boost comparison.
Separate studies, not a head-to-head trial. Source-checked conclusions do not validate older numerical estimates.
Source-checked conclusion: supported
St. John’s wort can help mild-to-moderate depression. It is not established for severe depression or long-term treatment.
Potentially serious medication interactions include antidepressants and reduced effectiveness of contraceptive pills. Prescriber review matters.
Population: Adults with mild-to-moderate depression. Formulation: Oral St. John’s wort preparations.
AI-assisted source check dated 2026-09-30. Selected effect only.
Read St. John's Wort profile, recorded doses, risks and available costs
Source-checked conclusion: uncertain
A meaningful benefit of omega-3 EPA/DHA supplements for depression remains uncertain. EPA-rich and DHA-rich products cannot be treated as interchangeable.
Low or very low certainty; formulations and trials differ. This is not evidence of a general mood boost or a replacement for depression treatment.
Population: People with depression in supplementation studies. Formulation: Oral omega-3 supplements containing EPA and/or DHA.
AI-assisted source check dated 2026-10-05. Selected effect only.
Read Omega-3 EPA/DHA profile, recorded doses, risks and available costs
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